李斌研究员2001年博士毕业于北京大学植物学专业，2001-2006年美国宾西法尼亚大学304am永利集团官网博士后、2006-2009年高级研究助理；2009年受聘"中科院百人计划"，任中科院上海巴斯德研究所课题组长；2016年起任上海市免疫学研究所资深课题组长、科研副所长。

李斌研究员长期从事免疫调节及重大免疫相关疾病如自身免疫病、过敏性疾病及恶性肿瘤相关基础及临床应用研究。近五年主持国家基金委免疫学杰青、重点、面上、中波国际合作等基金。T细胞免疫调控机制：FOXP3+T细胞具有重要的免疫抑制功能，李斌课题组对于Treg细胞的稳定性、FOXP3翻译后修饰、FOXP3蛋白复合体等调节机制进行了系统的分析。李斌课题组在国际学术刊物如J BIOL CHEM、J IMMUNOL cutting edge、J VIROL、PLOS Pathogens、PNAS、NAT COMMS、 GASTROENTEROLOGY、 IMMUNITY、NAT IMMUNOL 等发表通讯及共同通讯作者论文60余篇。 现任European Journal of Immunology全球12名执行编委会成员之一。获国家科技进步二等奖（2018）、上海医学科技奖、中华医学科技奖等奖励。

近五年发表论文：

1. Guo Y#, Chen J#, Huang Y, Ke S, Xie F, Li D, Li B*, Lu H*. Increased infiltration of CD4+ IL-17A+ FOXP3+ T cells in Helicobacter pylori-induced gastritis. Eur J Immunol. 2024 Mar;54(3):e2350662. doi: 10.1002/eji.202350662. Epub 2024 Feb 17. PMID: 38366919.

2. Liu X#, Zhang W#, Han Y#, Cheng H#, Liu Q#, Ke S, Zhu F, Lu Y, Dai X, Wang C, Huang G, Su B, Zou Q, Li H, Zhao W, Xiao L, Lu L, Tong X, Pan F*, Li H*, Li B*. FOXP3+ regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity. Nat Commun. 2024 Jan 2;15(1):122. doi: 10.1038/s41467-023-44391-9. PMID: 38167862; PMCID: PMC10761945.

3. Wang Z, Qin Z, Wang J, Xu X, Zhang M, Liang Y, Huang Y, Yu Z, Gong Y, Zhou L, Qiu Y, Ma M, Li D*, Li B*. Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation. J Dermatolog Treat. 2023 Dec;34(1):2220445. doi: 10.1080/09546634.2023.2220445. Epub 2023 Jun 15. PMID: 38073229.

4. Guo Y, Xie F, Liu X, Ke S, Chen J, Zhao Y, Li N, Wang Z, Yi G, Shen Y, Li D, Zhu C, Zhang Z, Zhao G, Lu H*, Li B*, Zhao W*. Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+ T regulatory cells. J Mol Cell Biol. 2023 Nov 3:mjad067. doi: 10.1093/jmcb/mjad067. Epub ahead of print. PMID: 37935468.

5. Yin H, Distler O, Shen L, Xu X, Yuan Y, Li R, Liu B, Li Q, Huang Q, Xie F, Zhang Z, Liang R, Dai X, Chen X, Li B*, Yan Q*, Lu L*. Endothelial Response to Type I Interferon Contributes to Vasculopathy and Fibrosis and Predicts Disease Progression of Systemic Sclerosis. Arthritis Rheumatol. 2024 Jan;76(1):78-91. doi: 10.1002/art.42662. PMID: 37488975.

6. Ke S#, Xie F#, Guo Y#, Chen J, Wang Z, Yu Y, Geng H, Xu D, Liu X, Xia X, Yu F, Zhu C, Zhang Z, Zhao G*, Li B*, Zhao W*. High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer. iScience. 2022 Nov 7;25(12):105529. doi: 10.1016/j.isci.2022.105529. PMID: 36419848; PMCID: PMC9676631.

7. Yang B, Deng B, Jiao XD, Qin BD, Lu Y, Zhang W, Guo Y, Chen S, Li D*, Li B*, Zang YS*. Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+T cells. Cell Oncol (Dordr). 2022 Dec;45(6):1297-1309. doi: 10.1007/s13402-022-00718-0. Epub 2022 Oct 19. PMID: 36260222.

8. Jian Z, Han Y, Zhang W, Li C, Guo W, Feng X, Li B*, Li H*. Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer. Cell Biosci. 2022 Aug 21;12(1):135. doi: 10.1186/s13578-022-00855-x. PMID: 35989326.

9. Deng B, Yang B, Chen J, Wang S, Zhang W, Guo Y, Han Y, Li H, Dang Y, Yuan Y, Dai X, Zang Y, Li Y*, Li B*. Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy. J Immunother Cancer. 2022 Jul;10(7):e004037. doi: 10.1136/jitc-2021-004037. Erratum in: J Immunother Cancer. 2022 Oct;10(10): PMID: 35817479.

10. Liang R, Yuan Y, Bai Y, Liu X, Chen J, Jiang D, Meng D, Chen G, Li B*, Zhou L*, Guo W*. Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation. Int Immunopharmacol. 2022 Sep;110:108953. doi: 10.1016/j.intimp.2022.108953. Epub 2022 Jun 17. PMID: 35724607.

11. Qu G, Chen J, Li Y, Yuan Y, Liang R, Li B*. Current status and perspectives of regulatory T cell-based therapy. J Genet Genomics. 2022 Jul;49(7):599-611. doi: 10.1016/j.jgg.2022.05.005. Epub 2022 May 28. PMID: 35636740.

12. Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H*, Li B*, Tong X*. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab. 2022 May;4(5):559-574. doi: 10.1038/s42255-022-00575-z. Epub 2022 May 23. PMID: 35606596.

13. Xu H, Zhu Z, Hu J, Sun J, Wo Y, Wang X, Zou H, Li B*, Zhang Y*. Downregulated cytotoxic CD8+ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids. Cell Mol Immunol. 2022 Apr;19(4):527-539. doi: 10.1038/s41423-021-00834-1. Epub 2022 Jan 17. PMID: 35039632; PMCID: PMC8975835.

14. Bao L, Bo XC, Cao HW, Qian C, Wang Z*, Li B*. Engineered T cells and their therapeutic applications in autoimmune diseases. Zool Res. 2022 Mar 18;43(2):150-165. doi: 10.24272/j.issn.2095-8137.2021.363. PMID: 35008131; PMCID: PMC8920845.

15. Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X*, Li B*. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Sep;22(9):1175-1185. doi: 10.1038/s41590-021-01010-3. Epub 2021 Aug 24. PMID: 34429546.

16. Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B*, Tong X*. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021 Aug;161(2):575-591.e16. doi: 10.1053/j.gastro.2021.04.041. Epub 2021 Apr 24. PMID: 33901495.

17. Liu Y, Du J, Liu X, Wang L, Han Y, Huang C, Liang R, Zheng F, Shi G*, Li B*. MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness. Signal Transduct Target Ther. 2021 Sep 8;6(1):321. doi: 10.1038/s41392-021-00667-4. PMID: 34493712; PMCID: PMC8423820.

18. Zhang W, Liu X, Zhu Y, Liu X, Gu Y, Dai X*, Li B*. Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease. Eur J Immunol. 2021 Jul 28. doi: 10.1002/eji.202048794. Epub ahead of print. PMID: 34322865.

19. Zhai T, Wang C, Xu Y, Huang W, Yuan Z, Wang T, Dai S, Peng S, Pang T, Jiang W, Huang Y, Zou Y, Xu Y, Sun J, Gong X, Zhang J, Tsun A*, Li B* & Miao X*. Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer. 2021 Jun;9(6):e002131. doi: 10.1136/jitc-2020-002131. PMID: 34172514; PMCID: PMC8237747.

20. Lin Y, Zhang D, Li Y, Li Y, Li B*, Du M*. Decidual NR2F2-Expressing CD4+ T Cells Promote TH2 Transcriptional Program During Early Pregnancy. Front Immunol. 2021 May 18;12:670777. doi: 10.3389/fimmu.2021.670777. PMID: 34084171; PMCID: PMC8168462.

21. Deng B, Zhang W, Zhu Y, Li Y, Li D, Li B*. FOXP3+ regulatory T cells and age-related diseases. FEBS J. 2021 Feb 2. doi: 10.1111/febs.15743. Epub ahead of print. PMID: 33529458.

22. Hou X, Zhu F, Ni Y, Chen T, Du J, Liu X, Han Y, Liu Y, Du W, Li Y, Wang X, Li D, Liang R, Li B*, Shi G*. USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response. Life Sci. 2021 Sep 15;281:119720. doi: 10.1016/j.lfs.2021.119720. Epub 2021 Jun 16. PMID: 34144056.

23. Liang CL, Lu W, Qiu F, Li D, Liu H, Zheng F, Zhang Q, Chen Y, Lu C, Li B, Dai Z. Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway. Biochem Pharmacol. 2021 Mar;185:114434.

24. Li H, Yu X, Shi B, Zhang K, Yuan L, Liu X, Wang P, Lv J, Meng G, Xuan Q, Wu W, Li B, Peng X, Qin X, Liu W, Zhong L, Peng Z. Reduced pannexin 1-IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients. Sci Transl Med. 2021 Aug 11;13(606):eaaz6169. doi: 10.1126/scitranslmed.aaz6169. PMID: 34380770.

25. Zeng F, Chen H, Chen L, Mao J, Cai S, Xiao Y, Li J, Shi J, Li B, Xu Y, Tan Z, Gong F, Li B, Qian Y, Dong L, Zheng F. An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis. J Invest Dermatol. 2021 Mar;141(3):596-606.e7.

26. Yang M, Huang Q, Li C, Jiang Z, Sun J, Wang Z, Liang R, Li D*, Li B*, Zhao H*. TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer. Front Immunol. 2021 Apr 9;12:647540. doi: 10.3389/fimmu.2021.647540.

27. Wang X, Cheng H, Shen Y, Li B*. Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function. Adv Exp Med Biol. 2021;1278:81-94.

28. Liu X, Meng X, Peng X, Yao Q, Zhu F, Ding Z, Sun H, Liu X, Li D, Lu Y, Tang H, Li B*, Peng Z*. Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis. Cell Death Dis. 2021 Apr 12;12(4):390.

29. Qian Y, Zhu Y, Li Y*, Li B*. Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases. Front Immunol. 2021 Feb 2;11:624411.

30. Zhang Y, Xiong DH, Li Y, Xu G, Zhang B, Liu Y, Zhang S, Huang Q, Chen S, Zeng F, Guo J, Li B, Qin Z, Zhang Z. Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice. J Immunol Res. 2021 Feb 9;2021:6613162. doi: 10.1155/2021/6613162. PMID: 33628844; PMCID: PMC7886505.

31. Zhu Y, Qian Y, Li Z, Li Y*, Li B*. Neoantigen-reactive T cell: An emerging role in adoptive cellular immunotherapy. MedComm (2020). 2021 Apr 23;2(2):207-220. doi: 10.1002/mco2.41. PMID: 34766142; PMCID: PMC8491202.

32. Liu X, Tian N, Huang Q, Xu Z, Cheng H, Liu X, Li D, Liang R, Li B*, Dai X*. hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells. FEBS Lett. 2021 Jul;595(14):1962-1974. doi: 10.1002/1873-3468.14142. Epub 2021 Jun 22. PMID: 34080184.

33. Qian SJ, Huang QR, Chen RY, Mo JJ, Zhou LY, Zhao Y, Li B*, Lai HC*. Single-Cell RNA Sequencing Identifies New Inflammation-Promoting Cell Subsets in Asian Patients With Chronic Periodontitis. Front Immunol. 2021 Sep 8;12:711337. doi: 10.3389/fimmu.2021.711337. PMID: 34566966; PMCID: PMC8455889.

34. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discov. 2021 Sep 28;7(1):89. doi: 10.1038/s41421-021-00321-x. PMID: 34580278; PMCID: PMC8476510.

35. Liu Y, Huang Q, Du J, Huang C, Li D, Dai X, Liang R, Li B*, Shi G*. Comparative analysis of global transcriptome, proteome and acetylome in house dust mite-induced murine allergic asthma model. Clin Transl Med. 2021 Nov;11(11):e590. doi: 10.1002/ctm2.590. PMID: 34841691; PMCID: PMC8571946.

36. Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J*, Zang YS*, Li B*. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+-Induced Regulatory T Cells. J Immunol. 2020 Sep 15;205(6):1497-1502. doi: 10.4049/jimmunol.2000136. Epub 2020 Aug 19. PMID: 32817370; PMCID: PMC7477744.

37. Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H*, Pan F*, Li B*. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep. 2020 Sep 3;21(9):e50308. doi: 10.15252/embr.202050308. Epub 2020 Jul 9. PMID: 32644293; PMCID: PMC7507386.

38. Gu W, Ge R, Zhu F, Li D, Liang R, Ge J, Wang Y, Li B, Qiu J. PARP-1 inhibitor-AG14361 suppresses acute allograft rejection via stabilizing CD4+FoxP3+ regulatory T cells. Pathol Res Pract. 2020 Aug;216(8):153021. doi: 10.1016/j.prp.2020.153021. Epub 2020 May 21. PMID: 32703489.

39. Yang M, Wang A, Li C, Sun J, Yi G, Cheng H, Liu X, Wang Z, Zhou Y, Yao G, Wang S, Liang R, Li B*, Li D*, Zhao H*. Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway. Front Oncol. 2020 Jul 30;10:1141. doi: 10.3389/fonc.2020.01141. PMID: 32850324; PMCID: PMC7406638.

40. Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis. Diabetes. 2020 Jul;69(7):1355-1367. doi: 10.2337/db19-1087. Epub 2020 Apr 15. PMID: 32295803.

41. Wang A, Yang M, Liang R, Zhu F, Zhu F, Liu X, Han Y, Lin R, Wang X, Li D, Li H, Yuan X, Zhao H*, Li B*. Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function. Front Immunol. 2020 Jun 19;11:1087. doi: 10.3389/fimmu.2020.01087. PMID: 32636834; PMCID: PMC7318079.

42. Gang Yi, Yi Zhao, Feng Xie, Fuxiang Zhu, Ziyun Wan, Xiu Qiu, Huanming Yang, Jian Wang, Bing Su, Lei Chen, Wei Zhang, Yong Hou, Xun Xu, Yinyan He, Andy Tsun, Xiao Liu, Bin Li*. Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin Volume 65, Issue 13, 15 July 2020, Pages 1114-1124.

43. Bai F, Zhang P, Fu Y, Chen H, Zhang M, Huang Q, Li D*, Li B*, Wu K*. Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. J Immunother Cancer. 2020 Apr;8(1):e000169. doi: 10.1136/jitc-2019-000169. PMID: 32300050; PMCID: PMC7204868.

44. Wang X, Yang Y, Ren D, Xia Y, He W, Wu Q, Zhang J, Liu M, Du Y, Ren C, Li B, Shen J, Zhang Y. JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300-mediated acetylation of RORγt. Br J Pharmacol. 2020 Jul;177(13):2959-2973. doi: 10.1111/bph.15023. Epub 2020 Mar 23. PMID: 32060899; PMCID: PMC7280011.

45. Zhao J, Zhang Y, Liu XS, Zhu FM, Xie F, Jiang CY, Zhang ZY, Gao YL, Wang YC, Li B*, Xia SJ*, Han BM*. RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Sci. 2020 Feb;111(2):369-382. doi: 10.1111/cas.14280. Epub 2020 Jan 4. PMID: 31833612; PMCID: PMC7004550.

46. Huang Q, Liu X, Zhang Y, Huang J, Li D*, Li B*. Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. J Genet Genomics. 2020 Jan 20;47(1):17-26. doi: 10.1016/j.jgg.2019.11.011. Epub 2020 Jan 24. PMID: 32081609.

47. Huang J, Wang S, Jia Y, Zhang Y, Dai X*, Li B*. Targeting FOXP3 complex ensemble in drug discovery. Adv Protein Chem Struct Biol. 2020;121:143-168. doi: 10.1016/bs.apcsb.2019.11.010. Epub 2020 Jan 7. PMID: 32312420.

48. Wang A, Zhu F, Liang R, Li D, Li B*. Regulation of T cell differentiation and function by ubiquitin-specific proteases. Cell Immunol. 2019 Jun;340:103922. doi: 10.1016/j.cellimm.2019.103922. Epub 2019 May 3. PMID: 31078284.

49. Zhao Y, Li X, Zhao W, Wang J, Yu J, Wan Z, Gao K, Yi G, Wang X, Fan B, Wu Q, Chen B, Xie F, Wu J, Zhang W, Chen F, Yang H, Wang J, Xu X, Li B, Liu S, Hou Y, Liu X. Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood. Gigascience. 2019 May 1;8(5):giz047. doi: 10.1093/gigascience/giz047. PMID: 31049560; PMCID: PMC6497034.

50. Ren J, Han L, Tang J, Liu Y, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function. PLoS Biol. 2019 May 24;17(5):e3000270. doi: 10.1371/journal.pbio.3000270. PMID: 31125332; PMCID: PMC6534289.

51. Nagai Y, Ji MQ, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, Fujimoto S, Goldberg MM, Zhang H, Li B, Ohtani T, Greene MI. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019 Feb 8;10:174. doi: 10.3389/fimmu.2019.00174. PMID: 30800128; PMCID: PMC6375878.

52. Ni X, Kou W, Gu J, Wei P, Wu X, Peng H, Tao J, Yan W, Yang X, Lebid A, Park BV, Chen Z, Tian Y, Fu J, Newman S, Wang X, Shen H, Li B, Blazar BR, Wang X, Barbi J, Pan F, Lu L. TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination. EMBO J. 2019 May 2;38(9):e99766. doi: 10.15252/embj.201899766. Epub 2019 Mar 18. PMID: 30886050; PMCID: PMC6484404.