曹克磊 助理研究员

邮箱: keleicao@sjtu.edu.cn

研究方向：

神经免疫调控

神经炎症在精神疾病中的作用及机制

小胶质细胞在睡眠及麻醉中的调控机制

教育及工作经历：

2011.09-2015.06；蚌埠304am永利集团官网；学士

2015.09-2018.06； 南京医科大学；硕士

2018.09-2022.06； 浙江大学；博士

2022.07-2024.08；浙江大学；博士后

论文发表

1.    Kelei Cao#, Liyao Qiu#, Xuan Lu, Weiying Wu, Yaling Hu, Zhicheng Cui, Chao Jiang, Yuxiang Luo, Yujin Shao, Wang Xi, Ling-Hui Zeng, Han Xu, Huan Ma, Zhi Zhang, Jiyun Peng, Shumin Duan*, Zhihua Gao*. Microglia modulate general anesthesia through P2Y12 receptor. Current Biology. 2023 May 6: S0960-9822(23)00529-8. doi: 10.1016/j.cub.2023.04.047. (Commented by Science, and highlighted by Lab Animals).

2.    Yaling Hu#; Kelei Cao# (Co-first author); Fang Wang#; Weiying Wu; Weihao Mai; Liyao Qiu; Yuxiang Luo; Wooping Ge; Binggui Sun; Ligen Shi; Junming Zhu; Jianmin Zhang; Zhiying Wu; Yicheng Xie; Shumin Duan*; Zhihua Gao*. Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity. Nature Metabolism. 2022, 4(12): 1756-1774. doi: 10.1038/s42255-022-00707-5. (Highlighted by Molecular Cell).

3.    Kelei Cao; Liao Xiang; Jiahui Lu; Shu Yao; Fengjiao Wu; Xingxing Zhu; Dongyan Shi; Shuang Wen; Lixin Liu; Hong Zhou. IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation. Journal of Neuroinflammation, 2018, 15(1). doi: 10.1186/s12974-018-1169-6.

4.    Kelei Cao, Yaling Hu, Zhihua Gao. Sense to Tune: Engaging Microglia with Dynamic Neuronal Activity. Neuroscience Bulletin. 2023 Mar;39(3):553-556. doi: 10.1007/s12264- 022-01010-9.

5.    Kelei Cao, Yaling Hu, Zhihua Gao. Brain Macrophages: Close or Distant Relatives?Neuroscience Bulletin. 2021 Feb;37(2):278-280. doi: 10.1007/s12264-020-00595-3.

6.    Yaling Hu#, Weihao Mai#, Lunhao Chen, Kelei Cao, Bin Zhang, Zhenjie Zhang, Yijun Liu, Huifang Lou, Shumin Duan, Zhihua Gao. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. GLIA. 2020 May;68(5):1031-1045. doi: 10.1002/glia.23760.

7.    Lunhao Chen#, Yaling Hu#, Siyuan Wang#, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Gao. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight. 2022 Nov 22;7(22): e159247. doi: 10.1172/jci.insight.159247.

8.    Xuan Lu#, Lunhao Chen#, Chao Jiang#, Kelei Cao, Zhihua Gao, Yue Wang. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2023 Feb 1;164(2):362-374. doi: 10.1097/j.pain.0000000000002708.

9.    Dongyan Shi#, Tongguan Tian#, Shu Yao, Kelei Cao, Xingxing Zhu, Mingshun Zhang, Shuang Wen, Longjun Li, Meiqing Shi, Hong Zhou. FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus. Brain Behavior Immunity. 2018 May;70 :293-304. doi: 10.1016/j.bbi.2018.03.009.

10.  Yawei Zhao, Dongyan Shi, Kelei Cao, Fengjiao Wu, Xingxing Zhu, Shuang Wen, Qiang You, Keqi Zhang, Lixin Liu, Hong Zhou. Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system. Journal of Leukocyte Biology. 2018 Jan;103(1):107-118. doi: 10.1002/JLB.3A0717-287R.

主持或参与基金项目

1.    获第九届中国科协“青年人才托举工程”项目支持 (2023-2026)；

2.    主持国家自然青年科学基金 (32300793, 2024-2026)；

3.    主持浙江省自然科学基金探索项目(Y24C090012, 2024-2026);

4.    主持中国博士后科学基金面上项目(2022M6722774)；

5.    作为骨干成员参与国家自然科学基金面上项目3项。

会议报告

1.    2024.09 中国神经科学年会“Neural-Immune Interactions in Health and Disease”

报告题目：The role of microglia in general anesthesia；汇报人:曹克磊

2.    2024.07 日本神经科学年会Travel Award

口头报告题目: Diverse roles of microglia in the brain；汇报人:曹克磊

3.    2023.08 中国高原脑科学论坛

口头报告题目: Microglia and general anesthesia；汇报人:曹克磊

4.    2023.09 长三角神经科学青年论坛

口头汇报题目: Diverse roles of microglia in the brain；汇报人:曹克磊

5.    2023.11 浙江省第十一届神经科学年会青年论坛

题目: Neuromodulation roles and intrinsic glucose metabolism characteristics of microglia  ；汇报人:曹克磊

6.    2022.12 浙江大学脑与脑机融合前沿科学中心青年博士论坛

题目: Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity；汇报人:曹克磊

专利

1.    高志华，曹克磊，邱礼耀，房丽丽，严敏，陆轩。P2Y12受体及其拮抗剂的用途。发明专利（已提交）

2.    高志华，曹克磊，邱礼耀，陆轩，胡亚玲，吴炜滢，彭吉云，段树民，房丽丽，严敏。CSF1R受体及其抑制剂的用途。发明专利（已提交）

获奖情况

2024.08 日本神经科学年会Travel Award；

2023.11 浙江省第十一届神经科学年会青年博士论坛二等奖；

2023.09 长三角神经科学青年论坛卓越博士后奖；

2022.11 浙江大学脑与脑机融合前沿科学中心青年博士论坛优秀奖.