Research

EAD8








Name:Yan Zhang

  • Office Location: 280 South Chongqing Road, Room 902, West #5 Building, Shanghai, China 200025

    Telephone: 021-63846590-776362

  • Email: zhy3331a@shsmu.edu.cn


Education：

B.S., China Pharmaceutical University, Nanjing, China      1999

Ph.D., Nanjing University, Nanjing, China (Mentor: Dr. Chenyu Zhang)    2003

Career：

2008-2014 Postdoctoral Fellow, National Cancer Institute, National Institutes of Health,  Bethesda, MD, USA (Mentor: Dr. Zhenggang Liu)

2016-2018 Staff Scientist, Children’s National Medical Center, Washington DC, USA

2018-2020  Research Associate, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA

2020-present Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China


Research Interests：

My research has focused on the fundamental mechanism of immune recognition and cancer biology, including both mechanisms that uncover the link between autoimmunity and cancer immunity, and on translating the new concept for production of new generation of cancer immunotherapeutic.

1. Zhang P, Xiong X, Rolfo C, Du X, Zhang Y, Yang H, Russo A, Devenport M, Zhou P, Liu Y#, Zheng P#. Mechanism- and Immune Landscape-Based Ranking of Therapeutic Responsiveness of 22 Major Human Cancers to Next Generation Anti-CTLA-4 Antibodies. Cancers (Basel), 2020, 12(2). pii: E284.

2. Wei Z*, Zhang Y*, Chen J*, Hu Y*, Jia P, Wang X, Zhao Q, Deng Y, Li N, Zang Y, Qin J, Wang X#, Lu W#. Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway. Sci Immunol, 2019, 29;4(41).

3. Zhang Y*#, Du X*, Liu M*, Tang F, Zhang P, Ai CX, Fields J, Sundberg E, Latinovic O, Devenport M, Zheng P# and Liu Y#. Hijacking Antibody-induced CTLA-4 Lysosomal Degradation for Safer and More Effective Cancer Immunotherapy. Cell Res, 2019, 29:607-629.

4. Du X*, Tang F*, Liu M, Su J, Zhang Y, Wu W, Devenport M, Lazarski C, Zhang P, Wang X, Ye P, Wang C, Hwang E, Zhu T, Xu T, Zheng P# and Liu Y#. A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Cell Res, 2018, 28(4):416-432.

5. Du X*, Liu M*, Su J, Zhang P, Tang F, Ye P, Devenport M, Wang X, Zhang Y, Liu Y# and Zheng P#. Uncoupling Therapeutic from Immunotherapy-related Adverse Effects for Safer and Effective Anti-CTLA-4 Antibodies in CTLA-4 Humanized Mice. Cell Res, 2018, 28(4):433-447.

6. Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng LX, Chao B, Zhang Y, Dawson VL, Dawson TM and Lenardo M. Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder. Nature Communications, 2014, Sep;5:4930.

7. Zhang Y, Choksi S, Liu ZG. Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis. Cancers (Basel), 2013, 5(4):1643-1654.

8. Zhang Y, Choksi S, Chen K, Pobezinskaya Y, Linnoila I, Liu ZG. ROS plays a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor associated macrophages. Cell Res, 2013, 23:898–914.

9. Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG. Induction of Autophagy is Essential for Monocyte-Macrophage Differentiation. Blood, 2012, 119(12):2895-2905.

10. Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol (2010) 11(9):799-805.



Lab Location:280 South Chongqing Road, Room 901, West #5 Building, Shanghai, China 200025

Tel:021-63846590-776795

Meiyu Zhang M.D

Assistant Research Fellow

E-mail：myzhang@shsmu.edu.cn

Kepeng Yan M.D

Assistant Research Fellow

E-mail：184499@shsmu.edu.cn

Song Mei

Postdoc

E-mail：san.shiban@163.com

Meijin Li

Ph.D. Candidate (Class 2021)

E-mail:18573136540@163.com
Benyu Wang
Ph.D.Candidate(Class 2022)
E-mail:wbysatm@sjtu.edu.cn		 Haoyue Zhou
Ph.D. Candidate(Class 2023)
E-mail:zhyhhn@outlook.com
Dongyang Li
Ph.D.Candidate(Class 2024)
E-mail:ldy1563597114@sjtu.edu.cn


                 

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