Research


Prof. Zhaojun Wang

Lab Location: 280 South Chongqing Road, Room 1211, West #5 Building, Shanghai, China 200025

Tel: 63846590-776349

Email: zjwang@sjtu.edu.cn


Education

B.M., Shanghai Second Medical University, Shanghai, China 1996

M.M., Shanghai Second Medical University, Shanghai, China 2002

Ph.D., Shanghai Jiao Tong University, Shanghai, China 2006

Career

1996-present, Assistant Teacher, Lecturer, Associate and Full Professor, Shanghai Jiao Tong University School of Medicine (Formerly Shanghai Second Medical University), Shanghai, China

2008-2012,Postdoctoral Researcher, University of Pennsylvania, Philadelphia, USA

2017-present, Vice Director, Faculty Development Department, Shanghai Jiao Tong University School of Medicine

2021-present, Principal Investigator, Shanghai Institute of Immunology, Shanghai, China

2023-present, Vice Dean, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine

Research Interests

Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Prof Wang’s lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens, such as protozoa and helminths.


Selected Publications

1. Du, X., Ren, B., Li, C., Li, Q., Kan, S., Wang, X., Bai, W., Wu, C., Kassegne, K., Yan, H., Niu, X., Yan, M., Xu, W., Wassmer, S.C., Wang, J.#, Chen, G.#,Wang, Z.#, PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.Nature communications2024, 15(1).

2. Lei, Y.; Guo, X.; Luo, Y.; Niu, X.; Xi, Y.; Xiao, L.; He, D.; Bian, Y.; Zhang, Y.; Wang, L.; Peng, X.#;Wang, Z.#; Chen, G.#, Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis.Nature communications2024, 15 (1).

3. Li, Q.; Yue, T.; Du, X.; Tang, Z.; Cui, J.; Wang, W.; Xia, W.; Ren, B.; Kan, S.; Li, C.; Wu, C.; Niu, X.; Li, B.; Lin, K.; Luo, J.; Chen, G.#;Wang, Z.#, HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction.Cell death and differentiation2023, 30 (3), 647-659.

4. Kan, S.; Li, Q.; Li, H. M.; Yao, Y. H.; Du, X. Y.; Wu, C. Y.; Chen, G. J.; Guo, X. K.; Qian, M. B.#;Wang, Z. J.#, Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.PLoS neglected tropical diseases2022, 16 (9), e0010726.

5. Wu, C.; Du, X.; Tang, L.; Wu, J.; Zhao, W.; Guo, X.; Liu, D.; Hu, W.; Helmby, H.; Chen, G.#;Wang, Z.#, Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE).Frontiers in immunology2020, 11, 1767.

6. Yin, C.; Wu, C.; Du, X.; Fang, Y.; Pu, J.; Wu, J.; Tang, L.; Zhao, W.; Weng, Y.; Guo, X.; Chen, G.#;Wang, Z.#, PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.Frontiers in immunology2018, 9, 2609.

7. Fayngerts, S. A.*;Wang, Z.*; Zamani, A.; Sun, H.; Boggs, A. E.; Porturas, T. P.; Xie, W.; Lin, M.; Cathopoulis, T.; Goldsmith, J. R.; Vourekas, A.; Chen, Y. H., Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.Nature immunology2017, 18 (12), 1353-1360.

8. Wu, C.; Chen, Q.; Fang, Y.; Wu, J.; Han, Y.; Wang, Y.; Yang, Y.; Chu, M.; Feng, Y.; Tan, L.; Guo, X.; Hu, W.;Wang, Z.#, Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation.PLoS neglected tropical diseases2014, 8 (2), e2703.

9.Wang, Z.*; Fayngerts, S.; Wang, P.; Sun, H.; Johnson, D. S.; Ruan, Q.; Guo, W.; Chen, Y. H., TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection.Proceedings of the National Academy of Sciences of the United States of America2012, 109 (38), 15413-8.

10.Wang, Z.*; Qiu, J.*; Guo, T. B.; Liu, A.; Wang, Y.; Li, Y.; Zhang, J. Z., Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis.Journal of immunology2007, 179 (9), 5958-65.

11.Wang, Z.*; Hong, J.*; Sun, W.; Xu, G.; Li, N.; Chen, X.; Liu, A.; Xu, L.; Sun, B.; Zhang, J. Z., Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs.The Journal of clinical investigation2006, 116 (9), 2434-41.

Chunyun Wu, Lecturer

Xinyue Du, Research associate

Yuewei Gao,Ph.D. candidate

Xiashun Li,Ph.D. candidate

Yuanyuan Li, M.S. candidate



                 

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