研究方向：

1. 干细胞参与肥胖、糖尿病等的调控作用

2. 神经干细胞衰老的表观遗传调控

3. 干细胞在肿瘤发生发展中的作用

课题及奖励：

1. 国家自然科学基金面上项目（2023.01-2026.12）

2. 国家自然科学基金青年项目（2016.01-2018.12）

3. 第51批中国博士后科学基金面上二等资助 (2012.06-2013.09)

4. 上海市博士后科研资助计划 (2012.09-2013.09)

5. 上海市卫生系统优秀青年人才培养计划（2014.01-2016.12）

6. 同济大学优秀人才培养计划（2011.12-2013.09）

7. 第48批中国博士后科学基金面上二等资助（2010.03-2011.08）

8. 山东省博士后创新项目专项资金一等资助（2011.03-2013.03）

9. 山东省优秀中青年科学家科研奖励基金（2011.02-2013.12）

授课：主讲干细胞与再生医学

代表性成果：

1. XL Wang#, SZh Yang#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Multi-omics profiles on small intestine organoids of comparisons between nutrition effects of breast milk and different infant formulae. Nutrients,2024 Aug22. https://www.mdpi.com/ 2072-6643/16/17/2951.

2. XL Wang#, YM Zhong#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Transcriptome and metabolome analyses reveal the effects of formula and breast milk on the growth and development of human small intestinal organoids. Food Res int,2024 Aug23. doi:org/10.1016/j.foodres.2024.114999.

3. XL Wang#, YX Jing#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids. Food Funct,2024 Aug19. doi: 10.1039 /d4fo01723d.

4. GM Wang, Ren, XH Zeng, X Chen, AB Liang, XL Wang*, Jun Xu*. Serine and arginine-rich splicing factor 3 promotes the activation of quiescent mouse neural stem cells. Stem Cells Dev, 2024 Jan 18. doi: 10.1089/scd.2023.0172.

5. YM Zhong, GM Wang, SZH Yang, Y Zhang, XL Wang. The role of DNA damage in neural stem cell. J Cell Physiol,2024 Jan 14. doi: 10.1002/ jcp. 31187.

6. HY Yao, YL Wu, YM Zhong, CX Huang, ZM Guo, YP Jin, XLWang. Role of c-Fos in DNA damage repair. J Cell Physiol,2024 Feb 7. doi: 10.1002/jcp. 31216.

7. HX Cheng, LY Hua, HL Tang, ZY Bao, XP Xu, HG Zhu, SY Wang, ZD Jiapaer, R Bhatia , Ian F. Dunn, JJ Deng, DJ Wang, XL Wang*, Y Gong*. CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44 /c-MY C/LDHA axis. J Mol Cell Biol,2023 Oct 3:mjad057. doi: 10.1093/jmcb/mjad057.

8. HY Liu, XL Wang. Esophageal organoids: applications and future prospects. J Mol Med, 2023,101:931-945.4.

9. YM Yan, Io Hong Cheong , PZ Chen, XG Li, XL Wang, H Wang. Patient-derived rectal cancer organoids-applications in basic and translational cancer research. Front Onco,2022 Jul 26:12:922430. doi: 10.3389/fonc.2022.922430. eCollection 2022.

10. J Ren#, XL Wang#, CM Dong#, GM Wang#, WJ Zhang, CH Cai, MQ Qian, DJ Yang, B Ling, K Ning, ZY Mao, BH Liu, TH Wang, LL Xiong, WY Wang, AB Liang, ZL Gao, J Xu. Sirt1 protects subventricular zone-derived neural stem cells from DNA double-strand breaks and contributes to olfactory function maintenance in aging mice. Stem Cells,2022 May 27;40(5):493-507. doi: 10.1093/stmcls/sxac008.

11. CM Dong#, XL Wang#, GM Wang#, LX Sun#, L Zhu, DJ Yang, S Gao, WJ hang, B Ling, AB Liang, ZL Gao, J Xu. ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway. Stem Cell Res,58 (2022)102618, https://doi.org /10. 1016/j.scr.2021.102618.

12. YP Jin, JY Wang, HC Li, SE Gao, RF Shi, DJ Yang, XL Wang, L Zhu, XJ Wang, CW Chen, K Ning, QC Fu, J Xu, ZL Gao. Extracellular vesicles secreted by human adipose-derived stem cells hASCs improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine,2018,34:231-242.

13. XL Wang, CX Sun, L Zhu, LX Sun, RJ Ma, ZG Wang, B Lu, X Chen, J Xu. Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells. Neuro Lett,2017,653: 355-361.

14. XL Wang, CM Dong, lX sun, L Zhu, CX Sun, RJ Ma, k Ning, JF Zhang, B Lu, J Xu. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep,2016,6,37443;doi:10.1038/ srep37443.

15. SE Gao, P Zhao, C Lin, YX Sun, YL Wang, ZC Zhou, DJ Yang, XL Wang, HZ Xu, F Zhou, LM Cao, W Zhou, K Ning, X Chen, J Xu. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three- dimensional scaffolds. Tissue Eng:Part A,2014,DOI: 10.1089/ten.tea.2012.0773.

16. CM Dong#, XL Wang#, GM Wang, WJ Zhang, L Zhu, S Gao, DJ Yang, Y Qin, QJ Liang, YL Chen, HT Deng, K Ning, AB Liang, ZL Gao, J Xu. A stress induced cellular aging model with postnatal neural stem cells. Cell Death Dis,2014 Mar13;5: e1116. doi: 10.1038/cddis. 2014.82.12.

17. DJ Yang#, XL Wang#, A Ismail, CJ Ashman, CF Valori, GM Wang, SE Gao, A Higginbottom, PG Ince, M Azzouz, J Xu, PJ Shaw, K Ning. PTEN regulates AMPA receptor- mediated cell viability in iPS-derived motor neurons. Cell Death Dis,2014 Feb 27;5:e1096. doi:10.1038/cddis.2014.55.

18. N Wang#, XL Wang#, CG Yang, XJ Zhao, YX Zhang, TZ Wang, SL Chen. Molecular cloning and multifunctional characterization of GRIM-19 homologue from turbot. Dev Comp Immunol,2014,43(1):96-105.

19. CG Yang#, XL Wang#, J Tian, W Liu, F Wu, M Jiang, H Wen. Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia. Gene,2013,527: 183- 192.

20. N Wang#, XL Wang#, CG Yang, SL Chen. Molecular cloning, subcelluar location and expression profile of signal transducer and activator of transcription 2 (STAT2) from turbot. Fish Shellfish Immun,2013,35:1200-1208.

21. XL Wang, YX Zhang, CG Yang, SL Chen. Cloning, characterization and expression analysis of Y-Box family members YB-1 in turbot. Fish Shellfish Immun,2012,33(5):1215-1221.

22. B Zhang#, XL Wang#, SL Chen. Establishment and characterization of a testicular cell line from half smooth tongue sole. Int J Bio Sci,2011,7(4):452-459.  

23. XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization of a new cell line from heart of half smooth tongue sole. Fish Physiol Biochem,2010,36:1181-1189.

24. N Wang#, XL Wang#, ZX Sha, YS Tian, SL Chen. Development and characterization of a new marine fish cell line from turbot. Fish Physiol Biochem,2010,36(4):1227-1234.

25. XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization, and virus susceptibility of a new marine cell line from spotted halibut. J Ocean U China,2010,9(2): 162-168.

26. ZX Sha#, GC Ren#, XL Wang#, N Wang, SL Chen. Development and characterization of a cell line from the embryos of half smooth tongue sole. Acta Oceanol Sin,2010,29(2):81-87.