徐雅倩

职称：助理研究员

地址：上海市黄浦区重庆南路280号1号楼412室

电话：021-63846590*776974

邮箱：xuyq1113@sjtu.edu.cn

工作经历

2023.12~至今，304am永利集团官网，全球健康学院，助理研究员

2021.11~2023.11，中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室-国科大杭州高等研究院环境学院，博士后

教育经历

2015.09~2021.08，同济大学，环境科学与工程学院，博士

2019.09~2020.10，哥本哈根大学，植物与环境科学学院，联合培养博士

2011.09~2015.06，上海海洋大学，水产与生命学院，学士

社会/学术任职和活动

2023~至今，Eco-Environment Health，青年编委

2023~至今，中国毒理学会，成员

2023~至今，中国化学会，成员

2019~至今，Society of Environmental Toxicology and Chemistry (SETAC)，成员

教授课程

负责《全球健康与全健康》“全球环境健康”章节教学

奖励

2024年度Eco-Environment Health期刊优秀青年编委

研究方向

环境污染与健康

研究兴趣

应用环境化学与流行病学等多学科研究方法，探讨环境中污染物与人体健康不良结局的关联，尤其关注具有Hormesis现象的污染物，为污染物的管控和人口可持续发展提供科学支撑。

科研项目

1. 304am永利集团官网“新进青年教师启动计划”(2023.12~2026.12)，全氟化合物暴露与美国成年人死亡的相关性研究，主持

2. 长江水环境教育部重点实验室开放基金(重点)(2022.01~2024.12)，合成酚类抗氧化剂及其转化产物在长江三角洲的赋存特征与联合风险评估(YRWEF202201)，主持

3. 国科大杭州高等研究院自主立项交叉项目课题(2022.12~2024.12)，典型工业热过程卤代芳烃类新污染物识别和催化转化的自由基机制研究(2022ZZ01017)，主持

4. 国科大杭州高等研究院博士后启动基金(2021.11~2023.11)，合成抗氧化剂及其转化产物的人体暴露特征与环境联合风险研究(B065C40723006)，主持

5. 中国科学院战略性先导科技专项(B类)课题(2023.12~2028.11)，新污染物多介质环境迁移与转化(XDB0750200)，骨干

6. 国家自然科学基金面上项目(2020.01~2023.12)，个人护理品时间依赖Hormesis及在混合物中的传递规律与机理探索(21976139)，骨干

7. 国家食品安全关键技术研发计划项目子课题(2018.12~2021.12)，混合污染物联合作用剂量-效应评价模型研究(2018YFC1603003)，骨干

8. 十三五水体污染控制与治理重大专项子课题(2017.01~2020.12)，标准外污染物浓度限值研究(2017ZX07201005)，骨干

9. 国家自然科学基金面上项目(2017.01~2020.12)，多元混合物合理有效表征及混合毒性预测模型研究(21677113)，骨干

代表性学术论文

1. Li, K., Li, X.W., Xu, Y.Q.* Chemical ingredients in personal care products and their hormetic effects on freshwater photobacteria. Journal of Environmental Exposure Assessment, 2024, 3, 30.

2. Xu, Y.Q., Hao, Y.Q., Chen, T.C., Li, X.W.* Structural and policy overview of medical education in Germany. Global Medicine Education, 2024, 1, 1-13.

3. Xu, Y.Q., Huang, P., Li, X.W., Liu, S.S., Lu, B.Q.* Derivation of water quality criteria for paraquat, bisphenol A and carbamazepine using quantitative structure-activity relationship and species sensitivity distribution (QSAR-SSD). Science of the Total Environment, 2024, 948, 174739.

4. Xu, Y.Q., Ding, T.T., Zhu, Q.Q., Tao, L., Liu, S. S., Hu, L.G., Liao, C.Y.* Ecological risk of synthetic phenolic antioxidants: A study based on their spatial distribution in water, sediment, and soil from the Yangtze River Delta. China. Environmental Research, 2024, 262(Pt 2), 119920.

5. Xu, Y.Q., Wang, T., Yin, J., Hu, L.G., Liao, C.Y.* The silent threat and countermeasures: Navigating the mixture risk of endocrine-disrupting chemicals on pregnancy loss in China. Eco-Environment Health, 2024, 3(3), 266-270.

6. Xu, Y.Q., Zhang, N., Hu, Y., Chen, F., Hu, L.G., Liao, C.Y.*, Jiang, G.B. A preliminary understanding of the relationship between synthetic phenolic antioxidants and early pregnancy loss: Uncovering the potential molecular mechanisms. Science of the Total Environment, 2024, 927, 171972.

7. Ding, T.T., Wang, Z.J., Tao, M.T., Gu, Z.W., Chen, R.J., Xu, Y.Q., Liu, S.S.* An innovative mixture sampling strategy with uniform design: Application to global sensitivity analysis of mixture toxicity. Environment International, 2024, 191, 108968.

8. Tao, M.T., Sun, X., Ding, T.T., Xu, Y.Q., Liu, S.S.* Screening for frequently detected quaternary ammonium mixture systems in waters based on frequent itemset mining and prediction of their toxicity. Ecotoxicology and Environmental Safety, 2024, 280, 116581.

9. Li, Y.T., Wang, X., Zhu, Q.Q., Xu, Y.Q., Fu, Q., Wang, T., Liao, C.Y.*, Jiang, G.B. Organophosphate flame retardants in pregnant women: Sources, occurrence, and potential risks to pregnancy outcomes. Environmental Science & Technology, 2023, 57(18), 7109-7128.

10. Xu, Y.Q., Hu, Y., Ding, T.T., Wang, Z.J., Wang, T., Hu, L.G., Liu, S.S., Liao, C.Y.*, Gan, J., Jiang, G.B. Novel macromolecular synthetic phenolic antioxidants in sludge on a national scale in China: Their distribution, potential transformation products, and ecological risk. Science of the Total Environment, 2023, 894, 164928.

11. Xu, Y.Q., Hu, Y., Wang, X., Hu, L.G., Liao, C.Y.*, Jiang, G.B. Profiles of novel high-molecular-weight synthetic antioxidants in urine and associated child exposure in China. Science of the Total Environment, 2023, 870, 161844.

12. Xu, Y.Q., Li, K., Wang, Z.J., Huang, P., Liu, S.S*. Transfer pattern of hormesis into personal care product mixtures from typical hormesis-inducing compounds. Science of the Total Environment, 2023, 855, 158981.

13. Huang, P., Wang, Y., Liu, S.S.*, Wang, Z.J., Xu, Y.Q. SAHmap: Synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans. Environmental Pollution, 2022, 315, 120378.

14. Huang, P., Liu, S.S.*, Wang, Z.J., Ding, T.T., Xu, Y.Q. Deriving the predicted no effect concentrations of 35 pesticides by the QSAR-SSD method. Chemosphere, 2022, 298, 134303.

15. Wang, Z.J., Zheng, Q. F., Liu, S.S.*, Huang, P., Ding, T.T., Xu, Y.Q. New methods of top-to-down mixture toxicity prediction: A case study of eliminating of the effects of cosolvent from binary mixtures. Chemosphere, 2022, 289, 133190.

16. Huang P., Liu S.S.*, Xu Y.Q., Wang Y., Wang Z.J. Combined lethal toxicities of pesticides with similar structures to Caenorhabditis elegans are not necessarily concentration additives. Environmental Pollution, 2021, 286, 117207.

17. Wang, Z.J., Liu, S.S.*, Huang, P., Xu, Y.Q. Mixture predicted no-effect concentrations derived by independent action model vs concentration addition model based on different species sensitivity distribution models. Ecotoxicology and Environmental Safety, 2021, 227, 112898.

18. Wang Z.J., Chen F., Xu Y.Q., Huang P., Liu S.S*. Protein model and function analysis in quorumsensing pathway of Vibrio qinghaiensis sp.-Q67. Biology-Basel, 2021, 10, 638.

19. Xu, Y.Q., Liu, S.S.*, Chen, F., Wang, Z.J. pH affects the hormesis profiles of personal care product components on luminescence of the bacteria Vibrio qinghaiensis sp. -Q67. Science of the Total Environment, 2020, 713, 136656.

20. Xu, Y.Q., Li, K., Wang, Z.J., Liu, S.S*. The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67. Environmental Sciences Europe, 2020, 32, 11.

21. Xu, Y.Q., Liu, S.S.*, Lu, B.Q., Wang, Z.J. Acute toxicity dataset for QSAR modeling and predicting missing data of six pesticides. Data in Brief, 2020, 29.

22. Huang, P., Li, K., Xu, Y.Q., Wang, Z.J., Liu, S.S*. Genetically modified Caenorhabditis elegans maylead to inaccurate toxicity evaluation of mixtures. Environmental Sciences Europe, 2020, 32(1), 63.

23. Lu, B.Q., Liu, S.S.*, Wang, Z.J., Xu, Y.Q. Conlecs: A novel procedure for deriving the concentration limits of chemicals outside the criteria of human drinking water using existing criteria and species sensitivity distribution based on quantitative structure-activity relationship prediction. Journal of Hazardous Materials, 2020, 384, 121380.

24. Wang, Z.J., Liu, S.S.*, Feng, L., Xu, Y.Q. BNNmix: A new approach for predicting the mixture toxicity of multiple components based on the back-propagation neural network. Science of the Total Environment, 2020, 738, 140317.

25. Wang, Y., Liu, S.S.*, Huang, P., Wang, Z.J., Xu, Y.Q. Assessing the combined toxicity of carbamate mixtures as well as organophosphorus mixtures to Caenorhabditis elegans using the locomotion behaviors as endpoints. Science of the Total Environment, 2020, 160, 143378.

26. Xu, Y.Q., Liu, S.S.*, Li, K., Wang, Z.J., Xiao, Q.F. Polyethylene glycol 400 significantly enhances the stimulation of 2-phenoxyethanol on Vibrio qinghaiensis sp.-Q67 bioluminescence. Ecotoxicology and Environmental Safety, 2019, 171, 240-246.

27. Xu, Y.Q., Liu, S.S.*, Wang, Z.J., Li, K., Qu, R. Commercial personal care product mixtures exhibit hormetic concentration-responses to Vibrio qinghaiensis sp.-Q67. Ecotoxicology and Environmental Safety, 2018, 162, 304-311.

28. Xu, Y.Q., Liu, S.S.*, Fan, Y., Li, K. Toxicological interaction of multi-component mixtures to Vibrio qinghaiensis sp.-Q67 induced by at least three components. Science of the Total Environment, 2018, 635, 432-442.

国家标准与软件著作权

1. 乳粉中三种多溴二苯醚(PBDEs)成分分析标准物质，国家标准物质定级证书，证书号：国标物证字第5127号，编号：GBW（E）100928(低浓度)，2023年7月14日，第四完成人。

2. 乳粉中三种多溴二苯醚(PBDEs)成分分析标准物质，国家标准物质定级证书，证书号：国标物证字第5127号，编号：GBW（E）100929(高浓度)，2023年7月14日，第四完成人。

3. 单个/混合物毒性拟合、预测与评估软件[简称：FPAsmt]1.0. 计算机软件著作权登记证书(证书号：软著登字第9049442号，登记号: 2022SR0095243，No. 10056721)，2022年01月14日，第三完成人。

Biography

Yaqian Xu, Ph.D.

Assistant Professor, School of Global Health, Shanghai Jiao Tong University

Office: +86-021-63846590*776974

Email: xuyq1113@sjtu.edu.cn

Office Address: Rm 412, Building 1, 280 South Chongqing Road, Shanghai

Dr. Xu is an assistant professor in the School of Global Health at Shanghai Jiao Tong University in China. Her academic journey includes earning bachelor's and Ph.D. degrees from Shanghai Ocean University and Tongji University, respectively. She pursued postdoctoral research at the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (RCEES, CAS) and the Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (UCAS). Additionally, she was a visiting Ph.D. at the University of Copenhagen in Denmark. With over 28 peer-reviewed scientific articles in international journals such as Environmental Science & Technology and Environmental Research, her work has garnered over 260 citations and an H-index of 12. She has served as a member in multiple organizations, including the European Society of Environmental Toxicology and Chemistry (SETAC), the Chinese Society of Toxicology, and the Chinese Chemical Society. Presently, she is involved in research initiatives such as the Strategic Priority Research Program of the Chinese Academy of Sciences and the Open Fund of the Key Laboratory of Yangtze River Water Environment, Ministry of Education.

Employment and Education Background

2023.12~now, Assistant Professor, School of Global Health, Shanghai Jiao Tong University

2021.11~2023.11, Post-doctorate, State Key Laboratory of Environmental Chemistry and Ecotoxicology, RCEES, CAS and School of Environment, Hangzhou Institute for Advanced Study, UCAS

2019.09~2020.10, Guest Ph.D., Department of Plant and Environmental Sciences, University of Copenhagen

2015.09~2021.08, Ph.D., College of Environmental Science and Engineering, Tongji University

2011.09~2015.06, B.S., College of Fisheries and Life Science, Shanghai Ocean University

Research Interests and Expertise

Dr. Xu's research aims to evaluate the environmental health risks posed by pollutants to humans. It uses interdisciplinary research methods such as environmental chemistry and epidemiology to explore the links between pollutants and adverse health outcomes, with a particular focus on pollutants exhibiting the hormesis phenomenon. The goal is to provide scientific evidence to support pollutant regulation and promote sustainable population development.