We focus on the comprehensive diagnosis and treatment of hemorrhagic diseases and thromboembolia, the construction of the diagnosis and control system of infectious diseases, the exploration of the epidemic and pathogenic mechanism of clinical pathogens, and the early diagnosis and precision treatment of tumors. By building a standardized testing collaboration platform, constantly consolidating basic research, closely docking clinical needs, and actively cultivating first-class teams, we aim to provide solid support for the health of the whole people, and make continuous contributions to the development of medical laboratory technology.

There are currently 40 full-time teachers, all of whom have doctoral degrees, including 20 senior professional titles; 17 doctoral supervisors and 20 master's supervisors; 2 winners of the National Outstanding Youth Fund, 1 Changjiang Scholar from the Ministry of Education, 1 Young Changjiang Scholar, 2 Leading Talents in Shanghai, and 2 Leading Talents in Health Care from the Shanghai Municipal Health Commission. In the past 5 years, we have undertaken more than 100 key projects of the Ministry of Science and Technology, general projects of the National Natural Science Foundation of China, National Natural Science Youth Fund, provincial and ministerial level projects, and have published over hundreds of high-quality papers in journals such as Nature Sustainability, Molecular Cell, Nature Communications, Nucleic Acids Research, Hepatology, Blood, Nature Microbiology and Cell Host & Microbe.

Research Interests 1：To provide comprehensive diagnosis and treatment strategies for hemorrhagic and thrombotic diseases

This discipline has built a comprehensive research and diagnosis platform for the pathogenesis of hemorrhagic and thrombotic diseases, and explored the development of new therapeutic drugs for hemophilia based on the exploration of the pathogenesis. Focus on developing phenotype diagnostic projects related to the diagnosis, treatment, and prognosis monitoring of hemorrhagic/thrombotic diseases, striving to form a complete system; On the basis of existing genetic diagnosis, to develop and improve the genetic diagnosis of hereditary hemorrhagic disease/thromboembolia, and strive to block the inheritance of the disease, to achieve the purpose of eugenics, to explore new types of anticoagulant and antithrombotic drugs and innovative gene therapy by elucidating the pathogenesis of hereditary hemorrhagic/thrombotic diseases. We have published over 100 papers as corresponding author in journals such as Blood, ATVB, Science Bulletin, and Haemologica.

Research Interests 2：To construct a new strategy of " diagnosis - prevention - control " for infectious diseases

To clarify the new mechanisms of epidemic pathogenesis and host defense based on the clinical needs of the prevention and control for important pathogen diagnosis, and develop new strategies for clinical practical diagnosis and control. The research mainly focuses on the molecular evolution of pathogen and translational research, pathogen infection and pathogenic mechanisms, and the application of translational research based on microfluidic technology. As the corresponding author, we have published over 80 papers in international professional SCI journals such as Nature Medicine, Nature Microbiology, Cell Host & Microbe, and the research had won the second prize of the 2018 National Science and Technology Progress Award (in third place).

Research Interests 3：To improve the application of new technologies in tumor diagnosis

To explore the key molecules in tumor signal transduction. based on the mechanism of these molecules, we attempted to further elucidate their potential as tumor markers, and develop new technologies to build and constantly improve the tumor testing methods. As the first/corresponding author, we have published 57 papers in international academic journals such as Nature Sustainability, Molecular Cell, Nature Communications, Nucleic Acids Research, Hepatology, etc. Among which, 25 papers were published in Zone 1 of the Chinese Academy of Sciences, 17 papers had IF>10 (a total of 14 in the past 5 years), and 5 ESI highly cited papers (a total of 4 in the past 5 years), with a maximum of 1218 citations of a single paper.

Research Interests 4：The application of inflammation biomarkers

The research mainly focuses on the discovery of inflammation biomarkers, precise diagnosis, the clinical translation of precise medicine. More than 80 articles have been published in prestigious international academic journals, such as Immunity, Nature Communications, PNAS, EMBO J, and Cancer Research as the first/main corresponding author.

Research Interests 5：Focused on exploring the omics atlas, pathogenesis, molecular diagnosis, and targeted intervention strategies for pediatric solid tumors.

Based on high-throughput sequencing and mass spectrometry technology, transcriptome/single-cell transcriptome, RNA methylation apparent transcriptome, proteome, metabolome, and protein modification profile analysis were conducted on pediatric tumors. Establish targets or molecular models for early diagnosis, treatment monitoring, and prediction of recurrence and metastasis in pediatric tumors. Using PDO and PDX models established by tumor tissue, establish a screening system for pediatric tumor-targeted drugs, study the relationship between different tumor susceptibility gene mutation profiles and targeted drugs, and search for molecular markers with drug resistance warning effects.

The Department of Clinical Nutrition of the School of Medicine and Technology of Shanghai Jiao Tong University was founded in 1986, formerly known as the Department of Medical Nutrition of Shanghai Second Medical University. After more than 30 years of development, it has become a first-class and internationally renowned clinical nutrition discipline base in China. The department is an important member unit of Shanghai Key Discipline of Medicine - Nutrition and health, the main construction unit of Shanghai Key discipline of public health Food nutrition and health, and the leading unit of China registered dietitian system pilot in Shanghai. For many years, this major has ranked first among the undergraduate majors of soft science in Chinese universities, and has cultivated a large number of high-quality and high-level nutrition professionals. In terms of scientific research, the Department has strong research strength in the research direction of diet and health, nutrition support for premature infants and early life nutrition, etc. It has won a number of national and provincial scientific research awards, including the second prize of National Science and Technology Progress, presided over a number of national and provincial scientific research projects, and ranked the forefront of clinical nutrition scientific research results published in domestic and foreign journals. Participated in the formulation of authoritative documents on Chinese dietary nutrition such as "Chinese Residents' Dietary Guidelines" and "Chinese Residents' Dietary Nutrient Reference Intake", and edited the clinical nutrition volume of "Chinese Nutrition Science". The Department focuses on the key scientific issues in the bottleneck of international and domestic nutrition disciplines, and focuses on the development of four disciplinary frontier directions: whole-life cycle nutrition and disease research, innovative research on dietary patterns and diseases, early screening technology for malnutrition, and new nutritional diagnosis and treatment technology, so as to provide strong support for the development of nutrition scientific research and the training of medical nutrition excellence talents.

In close cooperation with Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Renji Hospital, Ruijin Hospital, Shanghai Institute of Pediatric Medicine and other top three hospitals and research institutions, the Department has conducted in-depth research on the influence of diet and nutrition on individual development and health in early life through rich clinical resources and mature basic research platforms. How to prevent and control various diseases by adjusting dietary structure and reasonable nutritional support, and promote the diet health and disease prevention of special groups (pregnant women, children, the elderly, vegetarian people); Develop and apply malnutrition early screening technologies to quickly and effectively identify malnutrition risks and provide timely nutrition interventions for children; Actively explore new nutritional diagnosis and treatment technologies, such as nutrition support therapy based on individualized nutrition assessment, and the use of nutrients to intervene in the course of disease. At the same time, attention is also paid to the clinical application effect and safety evaluation of these new nutritional diagnosis and treatment technologies.

Medical imaging is an interdisciplinary field that combines modern life sciences, medicine, electronics, and computer science, and is one of the most important clinical diagnostic methods. The Department of Medical Imaging Technology at the School of Medical Technology, Shanghai Jiao Tong University School of Medicine, offers both master's and doctoral programs, and a postdoctoral research station. It has been selected as part of the Shanghai High-Level University Program and the Doctoral Talent Cultivation Plan. With the vision of "steadfast purpose and precision in talent cultivation," the program aims to nurture outstanding imaging innovation talents with an international perspective. The development of the imaging technology discipline is based on the integration of medicine and engineering, with medical imaging technology and artificial intelligence as the driving forces. Key research areas include magnetic resonance imaging (MRI) techniques and applications, intelligent medical imaging and big data, and molecular imaging.

Research Interest 1: MRI techniques

Develop advanced MRI technologies, including magnetic resonance metabolic imaging (such as multinuclear spectroscopy imaging and chemical exchange saturation transfer imaging), functional imaging (BOLD imaging, arterial spin labeling, etc.), and high-resolution structural imaging (diffusion imaging, susceptibility-weighted imaging, etc.). The focus is on the clinical application of these technologies in organs such as the brain, liver, and heart, promoting the overall advancement of MRI diagnostic and therapeutic techniques.

Research Interest 2: Molecular imaging

Develop nanomolecular probes that specifically target biomolecules in cells (such as receptors, enzymes, and proteins) for early disease diagnosis and treatment evaluation. Also, develop multimodal probes capable of imaging under different modalities (MRI/CT/optical/ultrasound, etc.), providing more comprehensive biological information. Additionally, develop intelligent responsive molecular probes to explore the pathological mechanisms of major diseases such as neurodegenerative and psychiatric disorders.

Research Interest 3: Intelligent medical imaging

Based on large-scale, multimodal imaging data for various diseases, develop new machine learning/deep learning algorithms to extract high-dimensional information from images that cannot be identified by the human eye. These algorithms enable early disease warning, diagnostic model optimization, and personalized treatment recommendations. The goal is to reveal the intrinsic connections between imaging features closely related to disease onset, progression, and outcomes, thereby improving the overall efficiency and quality of imaging diagnostics.

Research Interests 1：Pathogenesis of deafness

The researchers have elucidated the damage mechanisms of key cells in the auditory pathway and clarified the susceptibility genes of hearing impairment and biomarkers of hereditary deafness by taking the environmental and genetic factors of deafness as the starting point. The results have been published in Natural Science Review, Nature Communications, Genetics in Medicine, eLife, and other journals as corresponding authors.

Research Interests 2：Artificial hearing reconstruction

Focusing on the auditory pathway, we are conducting basic and clinical translational research to explore the sensory reconstruction brain-computer interface technology represented by ABI. The relevant research has been successfully translated into clinical trials, and the safety and efficacy registrations will be completed in 2023.

Research Interests 3：Inner ear gene therapy

Using CRISPR/Cas9 gene editing technology and viral vectors combined with gene replacement, gene editing, and other inner ear gene therapies for the treatment of hereditary hearing loss and clinical realization. The results have been published in Signal Transduction and Targeted Therapy, Molecular Therapy, and other journals as corresponding author.

Research Interests 4：Hearing health product development

Focusing on hearing disease research, we have actively built a multidisciplinary interdisciplinary cooperation model of medical-physical-industrial cooperation, and based on a large sample of clinical cohorts of people with hearing loss, we have explored the underlying pathological mechanisms and clinical characteristics. Through high-throughput sequencing technology, we accurately analyze the genetic variations and molecular mechanisms associated with hearing loss; at the same time, we use advanced data mining algorithms and artificial intelligence (AI) technology to assist in clinical diagnostic and treatment decision-making, and develop hearing health products using the latest technology in conjunction with clinical needs to help screening, diagnosis, intervention, and rehabilitation, and to improve diagnostic and treatment efficiency and accuracy.

Research Interests 5：Mechanism of noise deafness

Through the large sample noise-exposed cohort study, the group explored the epidemiological characteristics of noise deafness revealed the genetic risk factors of noise deafness in the high prevalence population, and screened and verified the genetic susceptibility gene AAK1, which is closely related to the occurrence and development of noise deafness, by using high-throughput technologies such as genomics, transcriptomics and other techniques, and combining with bioinformatic analyses; the group studied the function of AAK1 in the inner ear and its regulatory network in noise deafness by using cellular and animal models. Using cellular and animal models to study the function of the Aak1 gene in the inner ear and its regulatory network in noise deafness, combined with an animal model of gradient-escalating chronic noise exposure, the group attempts to elucidate the molecular pathological process of noise deafness, reveal how noise deafness susceptibility genes affect hearing loss, construct a molecular pathology map of noise deafness, discover potential therapeutic targets, and develop an effective strategy for the prevention and treatment of noise deafness.